Panama is about 1.6 times smaller than Mississippi.

Mississippi is approximately 121,489 sq km, while Panama is approximately 75,420 sq km, making Panama 62.08% the size of Mississippi. Meanwhile, the population of Mississippi is ~3.0 million people (1.4 million more people live in Panama).
This to-scale comparison of Mississippi vs. Panama uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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