Mississippi is about 1.6 times bigger than Panama.

Panama is approximately 75,420 sq km, while Mississippi is approximately 121,489 sq km, making Mississippi 61% larger than Panama. Meanwhile, the population of Panama is ~4.3 million people (1.4 million fewer people live in Mississippi).
This to-scale comparison of Panama vs. Mississippi uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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