Panama is about 3.6 times smaller than Colorado.

Colorado is approximately 268,627 sq km, while Panama is approximately 75,420 sq km, making Panama 28.08% the size of Colorado. Meanwhile, the population of Colorado is ~5.0 million people (691,428 fewer people live in Panama).
This to-scale comparison of Colorado vs. Panama uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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