Panama is about 426 times bigger than District of Columbia.

District of Columbia is approximately 177 sq km, while Panama is approximately 75,420 sq km, making Panama 42,510% larger than District of Columbia. Meanwhile, the population of District of Columbia is ~693,645 people (3.9 million more people live in Panama).
Tip: This to-scale comparison of District of Columbia vs. Panama uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.