District of Columbia is about 426 times smaller than Panama.

Panama is approximately 75,420 sq km, while District of Columbia is approximately 177 sq km, making District of Columbia 0.23% the size of Panama. Meanwhile, the population of Panama is ~4.3 million people (3.7 million fewer people live in District of Columbia).
Tip: This to-scale comparison of Panama vs. District of Columbia uses the Mercator projection, which distorts the size of regions near the poles.
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