Wyoming is about 1,421 times bigger than District of Columbia.

District of Columbia is approximately 177 sq km, while Wyoming is approximately 251,489 sq km, making Wyoming 141,984% larger than District of Columbia. Meanwhile, the population of District of Columbia is ~601,723 people (38,097 fewer people live in Wyoming).
Tip: This to-scale comparison of District of Columbia vs. Wyoming uses the Mercator projection, which distorts the size of regions near the poles.