District of Columbia is about 1,421 times smaller than Wyoming.

Wyoming is approximately 251,489 sq km, while District of Columbia is approximately 177 sq km, making District of Columbia 0.07% the size of Wyoming. Meanwhile, the population of Wyoming is ~563,626 people (38,097 more people live in District of Columbia).
Tip: This to-scale comparison of Wyoming vs. District of Columbia uses the Mercator projection, which distorts the size of regions near the poles.