West Virginia is about 352 times bigger than District of Columbia.

District of Columbia is approximately 177 sq km, while West Virginia is approximately 62,361 sq km, making West Virginia 35,132% larger than District of Columbia. Meanwhile, the population of District of Columbia is ~601,723 people (1.3 million more people live in West Virginia).
Tip: This to-scale comparison of District of Columbia vs. West Virginia uses the Mercator projection, which distorts the size of regions near the poles.