South Carolina is about 127 times bigger than Saint Lucia.

Saint Lucia is approximately 616 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 12,560% larger than Saint Lucia. Meanwhile, the population of Saint Lucia is ~167,122 people (4.5 million more people live in South Carolina).
Tip: This to-scale comparison of Saint Lucia vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles.