Missouri is about 1,961 times bigger than Anguilla.

Anguilla is approximately 91 sq km, while Missouri is approximately 178,414 sq km, making Missouri 195,959% larger than Anguilla. Meanwhile, the population of Anguilla is ~18,741 people (6.0 million more people live in Missouri).
Tip: This to-scale comparison of Anguilla vs. Missouri uses the Mercator projection, which distorts the size of regions near the poles.