Guyana is about 223 times bigger than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Guyana is approximately 214,969 sq km, making Guyana 22,200% larger than Sao Tome and Principe. Meanwhile, the population of Sao Tome and Principe is ~217,164 people (572,519 more people live in Guyana).
This to-scale comparison of Sao Tome and Principe vs. Guyana uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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