Afghanistan is about 9 times bigger than Panama.

Panama is approximately 75,420 sq km, while Afghanistan is approximately 652,230 sq km, making Afghanistan 765% larger than Panama. Meanwhile, the population of Panama is ~4.3 million people (34.0 million more people live in Afghanistan).
This to-scale comparison of Panama vs. Afghanistan uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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