Santiago is about 18 times bigger than Manchester.

Manchester is approximately 116 sq km, while Santiago (area of the 32 comunas of Santiago Province) is approximately 2,030 sq km, making Santiago 1,656% larger than Manchester.
Tip: This to-scale comparison of Manchester vs. Santiago uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.