Santiago is about 1.7 times bigger than Los Angeles.

Los Angeles (including the city proper only) is approximately 1,215 sq km, while Santiago (area of the 32 comunas of Santiago Province) is approximately 2,030 sq km, making Santiago 67% larger than Los Angeles.
Tip: This to-scale comparison of Los Angeles vs. Santiago uses the Mercator projection, which distorts the size of regions near the poles.
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