Los Angeles is about 1.7 times smaller than Santiago.

Santiago (area of the 32 comunas of Santiago Province) is approximately 2,030 sq km, while Los Angeles (including the city proper only) is approximately 1,215 sq km, making Los Angeles 59.83% the size of Santiago.
Tip: This to-scale comparison of Santiago vs. Los Angeles uses the Mercator projection, which distorts the size of regions near the poles.
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