Santa Ana is about 1.7 times smaller than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Santa Ana (map shows its 60 named neighbourhoods; the area covers the whole city) is approximately 71 sq km, making Santa Ana 58.6% the size of San Francisco.
Tip: This to-scale comparison of San Francisco vs. Santa Ana uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.