San Francisco is about 2.6 times smaller than Rotterdam.

Rotterdam (map shows its 22 named neighbourhoods; the area covers the whole city) is approximately 319 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 37.89% the size of Rotterdam.
Tip: This to-scale comparison of Rotterdam vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.