Rotterdam is about 2.6 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Rotterdam (map shows its 22 named neighbourhoods; the area covers the whole city) is approximately 319 sq km, making Rotterdam 164% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Rotterdam uses the Mercator projection, which distorts the size of regions near the poles.
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