Rome is about 1.6 times smaller than Santiago.

Santiago (area of the 32 comunas of Santiago Province) is approximately 2,030 sq km, while Rome is approximately 1,287 sq km, making Rome 63.41% the size of Santiago.
Tip: This to-scale comparison of Santiago vs. Rome uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.