Rome is about 2.2 times bigger than Chicago.

Chicago is approximately 590 sq km, while Rome is approximately 1,287 sq km, making Rome 118% larger than Chicago.
Tip: This to-scale comparison of Chicago vs. Rome uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.