Los Angeles is about 17 times bigger than Santa Ana.

Santa Ana (map shows its 60 named neighbourhoods; the area covers the whole city) is approximately 71 sq km, while Los Angeles (including the city proper only) is approximately 1,215 sq km, making Los Angeles 1,613% larger than Santa Ana.
Tip: This to-scale comparison of Santa Ana vs. Los Angeles uses the Mercator projection, which distorts the size of regions near the poles.
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