Los Angeles is about 5 times bigger than Des Moines.

Des Moines (map shows its 58 named neighbourhoods; the area covers the whole city) is approximately 228 sq km, while Los Angeles (including the city proper only) is approximately 1,215 sq km, making Los Angeles 432% larger than Des Moines.
Tip: This to-scale comparison of Des Moines vs. Los Angeles uses the Mercator projection, which distorts the size of regions near the poles.
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