Des Moines is about 5 times smaller than Los Angeles.

Los Angeles (including the city proper only) is approximately 1,215 sq km, while Des Moines (map shows its 58 named neighbourhoods; the area covers the whole city) is approximately 228 sq km, making Des Moines 18.8% the size of Los Angeles.
Tip: This to-scale comparison of Los Angeles vs. Des Moines uses the Mercator projection, which distorts the size of regions near the poles.
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