Fort Wayne is about 2.4 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Fort Wayne (map shows its 315 named neighbourhoods; the area covers the whole city) is approximately 289 sq km, making Fort Wayne 139% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Fort Wayne uses the Mercator projection, which distorts the size of regions near the poles.
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