South Carolina is about 92 times bigger than San Diego.

San Diego is approximately 844 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 9,139% larger than San Diego.
Tip: This to-scale comparison of San Diego vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.