Maine is about 452 times bigger than District of Columbia.

District of Columbia is approximately 177 sq km, while Maine is approximately 79,931 sq km, making Maine 45,059% larger than District of Columbia. Meanwhile, the population of District of Columbia is ~601,723 people (726,638 more people live in Maine).
Tip: This to-scale comparison of District of Columbia vs. Maine uses the Mercator projection, which distorts the size of regions near the poles.