Indiana is about 525 times bigger than District of Columbia.

District of Columbia is approximately 177 sq km, while Indiana is approximately 92,895 sq km, making Indiana 52,383% larger than District of Columbia. Meanwhile, the population of District of Columbia is ~601,723 people (5.9 million more people live in Indiana).
Tip: This to-scale comparison of District of Columbia vs. Indiana uses the Mercator projection, which distorts the size of regions near the poles.