San Francisco is about 4.4 times bigger than O'Hare Airport.

O'Hare Airport is approximately 27 km² (11 sq mi), while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 342% larger than O'Hare Airport.
Tip: This to-scale comparison of O'Hare Airport vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
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