San Francisco is about 13 times bigger than Mackinac Island.

Mackinac Island is approximately 9.54 km² (3.68 sq mi), while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 1,168% larger than Mackinac Island.
Tip: This to-scale comparison of Mackinac Island vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
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