Flathead Lake is about 2.2 times bigger than Martha's Vineyard.

Martha's Vineyard is approximately 227 km² (87 sq mi), while Flathead Lake is approximately 510 km² (197 sq mi), making Flathead Lake 125% larger than Martha's Vineyard.
Tip: This to-scale comparison of Martha's Vineyard vs. Flathead Lake uses the Mercator projection, which distorts the size of regions near the poles.
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