Colosseum is about 6,269 times smaller than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Colosseum is approximately 0.019 km² (0.0075 sq mi), making Colosseum 0.02% the size of San Francisco.
Tip: This to-scale comparison of San Francisco vs. Colosseum uses the Mercator projection, which distorts the size of regions near the poles.
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