Size comparison

compared to

Biltmore Estate is about 13 times smaller than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Biltmore Estate is approximately 9.27 km² (3.58 sq mi), making Biltmore Estate 7.66% the size of San Francisco.
Tip: This to-scale comparison of San Francisco vs. Biltmore Estate uses the Mercator projection, which distorts the size of regions near the poles.
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Compare further: Biltmore Estate vs. San Francisco

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See Biltmore Estate on top of San Francisco
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