Syria is about 2.5 times bigger than Panama.

Panama is approximately 75,420 sq km, while Syria is approximately 187,437 sq km, making Syria 149% larger than Panama. Meanwhile, the population of Panama is ~4.3 million people (17.2 million more people live in Syria).
This to-scale comparison of Panama vs. Syria uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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