South Carolina is about 2.3 times smaller than Uruguay.

Uruguay is approximately 176,215 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 44.25% the size of Uruguay. Meanwhile, the population of Uruguay is ~3.4 million people (1.2 million more people live in South Carolina).
This to-scale comparison of Uruguay vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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