South Carolina is about 2,999 times bigger than Tuvalu.

Tuvalu is approximately 26 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 299,835% larger than Tuvalu. Meanwhile, the population of Tuvalu is ~11,544 people (4.6 million more people live in South Carolina).
Tip: This to-scale comparison of Tuvalu vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles.