South Carolina is around the same size as Panama.

Panama is approximately 75,420 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 3% larger than Panama. Meanwhile, the population of Panama is ~4.3 million people (287,596 more people live in South Carolina).
This to-scale comparison of Panama vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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