South Carolina is about 2.2 times bigger than Guinea-Bissau.

Guinea-Bissau is approximately 36,125 sq km, while South Carolina is approximately 77,983 sq km, making South Carolina 116% larger than Guinea-Bissau. Meanwhile, the population of Guinea-Bissau is ~2.0 million people (2.6 million more people live in South Carolina).
This to-scale comparison of Guinea-Bissau vs. South Carolina uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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