Oregon is about 258 times bigger than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Oregon is approximately 248,631 sq km, making Oregon 25,692% larger than Sao Tome and Principe. Meanwhile, the population of Sao Tome and Principe is ~217,164 people (3.6 million more people live in Oregon).
Tip: This to-scale comparison of Sao Tome and Principe vs. Oregon uses the Mercator projection, which distorts the size of regions near the poles.