Guyana is about 488,566 times bigger than Holy See (Vatican City).

Holy See (Vatican City) is approximately 0 sq km, while Guyana is approximately 214,969 sq km, making Guyana 48,856,491% larger than Holy See (Vatican City). Meanwhile, the population of Holy See (Vatican City) is ~1,000 people (788,683 more people live in Guyana).
This to-scale comparison of Holy See (Vatican City) vs. Guyana uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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