Guinea is about 255 times bigger than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Guinea is approximately 245,857 sq km, making Guinea 25,404% larger than Sao Tome and Principe. Meanwhile, the population of Sao Tome and Principe is ~217,164 people (13.0 million more people live in Guinea).
This to-scale comparison of Sao Tome and Principe vs. Guinea uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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