Detroit is about 2.7 times smaller than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Detroit is approximately 359 sq km, making Detroit 37.27% the size of Sao Tome and Principe.
Tip: This to-scale comparison of Sao Tome and Principe vs. Detroit uses the Mercator projection, which distorts the size of regions near the poles.