Colorado is about 279 times bigger than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Colorado is approximately 268,627 sq km, making Colorado 27,766% larger than Sao Tome and Principe. Meanwhile, the population of Sao Tome and Principe is ~217,164 people (4.8 million more people live in Colorado).
Tip: This to-scale comparison of Sao Tome and Principe vs. Colorado uses the Mercator projection, which distorts the size of regions near the poles.