Cayman Islands is about 286 times smaller than Panama.

Panama is approximately 75,420 sq km, while Cayman Islands is approximately 264 sq km, making Cayman Islands 0.35% the size of Panama. Meanwhile, the population of Panama is ~4.3 million people (4.3 million fewer people live in Cayman Islands).
This to-scale comparison of Panama vs. Cayman Islands uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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