Alaska is about 52,530 times bigger than Macau.

Macau is approximately 28 sq km, while Alaska is approximately 1,481,348 sq km, making Alaska 5,252,907% larger than Macau. Meanwhile, the population of Macau is ~635,293 people (74,938 more people live in Alaska).
Tip: This to-scale comparison of Macau vs. Alaska uses the Mercator projection, which distorts the size of regions near the poles.