San Mateo is about 3.9 times smaller than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while San Mateo is approximately 31 sq km, making San Mateo 25.97% the size of San Francisco.
Tip: This to-scale comparison of San Francisco vs. San Mateo uses the Mercator projection, which distorts the size of regions near the poles.
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