San Francisco is around the same size as Vancouver.

Vancouver (map shows its 61 named neighbourhoods; the area covers the whole city) is approximately 126 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 95.73% the size of Vancouver.
Tip: This to-scale comparison of Vancouver vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.