San Francisco is about 11 times smaller than Rome.

Rome is approximately 1,287 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 9.4% the size of Rome.
Tip: This to-scale comparison of Rome vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.