San Francisco is around the same size as Eugene.

Eugene is approximately 115 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 5% larger than Eugene.
Tip: This to-scale comparison of Eugene vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.