San Francisco is about 4.6 times bigger than Charlottesville.

Charlottesville is approximately 27 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 356% larger than Charlottesville.
Tip: This to-scale comparison of Charlottesville vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
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