San Francisco is about 1.7 times smaller than Buenos Aires.

Buenos Aires is approximately 203 sq km, while San Francisco (including the city proper only) is approximately 121 sq km, making San Francisco 59.52% the size of Buenos Aires.
Tip: This to-scale comparison of Buenos Aires vs. San Francisco uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.